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Principal Investigator:



Susan Marqusee, MD, Ph.D
Professor of Molecular and Cell Biology, Division of Biochemistry and Molecular Biology. Susan received her A.B. in Physics and Chemistry from Cornell University in 1982, and her M.D. and Ph.D. degrees from Stanford University in 1990. After a post-doctoral fellowship at MIT, she joined the UC Berkeley faculty as Assistant Professor in 1992, advancing to Associate and Full Professor in 1998 and 2001 respectively.



Postdocs:


Katie Tripp, Ph.D
ktripp@berkeley.edu
Using directed evolution to generate a large set of homologous proteins with variable thermostability in order to gain insight into how sequence determines the behavior of proteins in solution.


Graduate Students:


Tracy Young - MCB

Jennifer Fostel - MCB
jfostel@berkeley.edu
Identifying sequence and biophysical differences between proteins from thermophilic and mesophilic bacteria.

Kath Ratcliff - Biophysics
Studying the role of heat capacity in defining the thermophilicity of proteins.

Geoff Horner - MCB
Studying energetic aspects of vitamin remediation in mutant proteins.

Phillip Elms - Biophysics
elms@berkeley.edu
Studying the transition state under mechanical perturbation using the optical tweezers in order to gain a better understanding of the mechanism of how proteins unfold and fold under mechanical stress.

Katelyn Connell - Chemical Biology
kconnell@berkeley.edu
Using a single-molecule mechanical tool, the optical tweezers, to dissect the cooperativity of the Notch ankyrin domain, a structurally modular protein.

Jesse Dill - Biophysics   (Marqusee/Bustamante)
jessedill@berkeley.edu
Using nonequilibrium statistical mechanics to study protein folding on a single-molecule level.

Katherine Miller - Biophysics
khmiller@berkeley.edu
Studying protein conformational changes in the context of disease regulation.

Rachel Bernstein - Chemical Biology
rachelsb@berkeley.edu
Developing a new technique for probing the differential stability of protein regions.

Roseanne Wincek - Biophysics   (Marqusee/H. Yang)
roseanne@berkeley.edu
Using single-molecule assays to study rarely sampled conformations in protein structures.

Ben Geller - Physics  
geller@berkeley.edu
Comparing the Optical Tweezers and AFM as methods to study protein folding.
Katie Hart - Chemical Biology  
kmhart@berkeley.edu
Designing and characterizing an allosteric protein switch based on mutually exclusive folding.


Undergraduates:


Angela Christensen - lab technician


Alumni:


2007:
Tanya Freedman - graduate student
Mayumi Pierce - undergraduate
2006:
Jason Cellitti - graduate student
David (Pete) Wildes - graduate student
2005:
Erin Kang - undergraduate
Ester Kwon - research assistant
Chiwook Park - postdoc
Elizabeth Shank - graduate student
2004:
Christina Karplus - undergraduate
Jackie Gilmore - undergraduate
Erik Miller - graduate student
Srebrenka Robic - graduate student
Eric Nicholson - postdoc
2003:
Neda Ghaffari - undergraduate
Kael Fischer - graduate student
2002:
Giulietta Spudich - graduate student
Kate Schubert - graduate student
2001:
Eric Goedken - graduate student
Julie Hollien - graduate student
Carol Rohl - postdoc
Sonja Lorenz - fellowship student
2000:
Martin Parker - postdoc
1999:
Manuel Llinás - graduate student
Tanya Raschke - graduate student
Gunther Kern - postdoc
1998:
Joan Kho - technician
1997:
Jim Keck - graduate student
Aaron Chamberlain - graduate student
1996:
Jon Dabora - graduate student
Dung Vu - technician
1995:
Mary Goodwin - undergrad